Evidence that HLA-G is the functional homolog of mouse Qa-2, the ped gene product
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چکیده
منابع مشابه
The expression pattern of the Qa-2 antigen in mouse preimplantation embryos and its correlation with the Ped gene phenotype.
The Qa-2 antigen, the product of the Ped (Preimplantation embryo development) gene, is a glycosylphosphatidylinositol-linked cell surface protein encoded in the Q region of the mouse major histocompatibility complex (MHC). Ped fast (Qa-2+) mouse strains have significantly higher preimplantation embryo cleavage rates both in vivo and in vitro than Ped slow (Qa-2-) mice. In this study, we determi...
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15 صفحه اولdown-regulation of hla-g attenuates cleavage rate in human triploid embryos
background: hla-g is a major histocompatibility complex (mhc), class ib molecule that is selectively expressed at the fetal–maternal interface. it is thought to play a role in protecting the fetus from the maternal immune response. interestingly, the preimplantation embryo development (ped) gene product qa-2 is also a mouse mhc class ib protein that affects cleavage and division of preimplantat...
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متن کاملSearch for a human homologue of the mouse Ped gene.
The Ped gene influences the rate of cleavage division of preimplantation mouse embryos and subsequent embryonic survival. The mouse Ped gene product is a major histocompatibility complex (MHC) class Ib protein called Qa-2. Studies from many human in-vitro fertilization (IVF) clinics suggest that the mouse Ped gene has a human homologue because embryos fertilized at the same time have different ...
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ژورنال
عنوان ژورنال: Human Immunology
سال: 2003
ISSN: 0198-8859
DOI: 10.1016/j.humimm.2003.08.352